CAFFEINE ANHYDROUS BP, USP |
Caffeine is classified by the US Food and Drug Administration as generally recognised as safe (GRAS). Toxic doses, over 10 grams per day for an adult, are much higher than the typical dose of under 500 milligrams per day, A cup of coffee contains 80–175 mg of caffeine, depending on what “bean” (seed) is used and how it is prepared (e.g., drip, percolation, or espresso). Thus it requires roughly 50–100 ordinary cups of coffee to reach the toxic dose. However, pure powdered caffeine, which is available as a dietary supplement, can be lethal in tablespoon-sized amounts.
Suggested Use: An average cup of coffee contains approximately 100mg of caffeine – use this product accordingly.
Storage: Store in a cool dry place. Keep away from strong light and heat.
Caution: This product is PURE CAFFEINE – care must be taken as small amounts can be very potent. Using a micro weighing-balance of high accuracy, is strongly recommended. Avoid prolonged exposure to skin. Do not inhale, and avoid contact with mucous membranes and eyes.
WARNINGS: Keep out of the reach of young children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet. Do not take during pregnancy or for prolonged periods without consulting a doctor.
Content | Standard | Results |
Appearance | White or almost white, crystalline powder (BP) or silky, white or almost white, crystals | White crystalline powder |
Identification
A. Melting point B. Infrared Absorption
C. Loss on drying |
234-239oC (BP) Conforms to the caffeine reference spectrum (BP)
See Tests (BP) |
236.2-237.0oC Pass
Pass |
Appearance on solution | Clear, colourless (BP) | Pass |
Heavy metals | ≤20ppm (BP) | <10ppm |
Sulphates | ≤500ppm (BP) | <500ppm |
Related substances | ||
Each impurity A, B ,C, D,E, F | ≤0.10% (BP) | <0.10% |
Unspecified impurities | ≤0.10% (BP) | <0.10% |
Total impurities | ≤0.1% (BP) | <0.1% |
Acidity | Not more than 0.2 ml of 0.01M sodium hydroxide (BP) | <0.2ml |
Organic impurities | ||
Individual impurities | ≤0.1% (USP) | <0.1% |
Total impurities | ≤0.1% (USP) | <0.1% |
Loss on drying | ≤0.5% (BP) | 0.10% |
Residue on ignition | ≤0.1% (USP) | 0.05% |
Assay | 98.5%-101.0% (USP) | 99.8% |
Conclusion: The above product conforms to BP2015, USP38 requirement on Caffeine.